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Figure 3 Circulating plasma endothelin 1 (ET-1) concentrations (radioimmunoassay). The circulating ET-1 concentration in the tacrolimus (closed bars) (but not in the cyclosporin A [open bars]) group decreased during the first 12 postoperative months. The absolute change in ET-1 concentration during follow-up was significantly different between the groups (p 0.05). baseline to follow-up = absolute change from baseline to follow-up. *p < 0.05 versus cyclosporin A.