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Figure 1 Photograph of a heart after myocardial contrast echocardiography in the open-chest model at 2.2 MPa. The blue band formed across the left ventricle at the ultrasound scan plane and records the microvascular leakage, with irregular erythrocyte extravasation in the center of the band (arrows). The vertical lines indicate the orientation of tissue slices used for samples A to E. Scale bar = 1 cm.