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Figure 4 (A to C) Representative immunohistochemical analysis of C-reactive protein (CRP), matrix metalloproteinases (MMP)-1, and -10 in adjacent sections of human atherosclerotic plaques. Area squared in red corresponds to magnified details. Higher magnification revealed intense positive signal for CRP, MMP-1, and MMP-10 within macrophage-rich areas (CD-68 positive) (D). Magnification detail of endothelial layer (x100) showed that endothelial cell, positive for von Willebrand factor (vWf), also expressed MMP-10 (E and F). (G to I) Inmmunolocalization of CRP, MMP-1, and MMP-10 in control mammary arteries.