Click on image to view larger version.

Figure 1 C-reactive protein (CRP) increases matrix metalloproteinase (MMP)-1 and MMP-10 messenger ribonucleic acid (mRNA) expression in human endothelial cell. Reverse transcription-polymerase chain reaction for MMP-1, -9, -10, and tissue inhibitor of metalloproteinases (TIMP)-1 mRNA was performed in CRP-stimulated human umbilical vein endothelial cells (HUVEC) (12 h, 50 µg/ml) and mRNA normalized values (target gene/ß-actin mRNA copies) obtained. C-reactive protein-induced MMP-1 and -10 expression in human aortic endothelial cell (HAEC) is also shown. Data are presented (mean ± SEM, n = 4) as percentage from controls set as 100%. *p < 0.05 compared with control.