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Figure 5 Molecular imaging of apoptosis in atherosclerosis using radiolabeled annexin (94). ^99mTc-radiolabeled annexin A5 accumulates in a carotid lesion (A, single-photon emission computed tomography images, arrows) of a patient with a recent transient ischemic attack (TIA). (B, D) Annexin A5 in sections of the resected plaque stains strongly (B, anti-annexin A5 polyclonal antibody, original magnification x400) in a macrophage-rich area. In contrast, minimal annexin A5 signal (C) appears in the carotid artery of a patient with a remote TIA. (D) Annexin A5 immunoreactivity is at a background level in the corresponding smooth muscle cell-rich lesion. Images provided courtesy of Dr. Bas Kietselaer and Dr. Leonard Hofstra, University Hospital of Maastricht, Maastricht, the Netherlands. Reproduced by permission from reference 94. ant = anterior; l = left.