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Figure 1 The biology of atherosclerosis initiation, progression, and complications. This road map identifies important targets for molecular imaging (Table 1). Imaging agents are available for a range of targets and imaging modalities, and several agents have been tested in clinical studies. Modified by permission from reference 10. CCR2 = chemokine (CC motif) receptor 2; MCP = monocyte chemoattractant protein; M-CSF = monocyte colony-stimulating factor; MMP = matrix metalloproteinase; ROS = reactive oxygen species; VCAM = vascular cell adhesion molecule.