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Figure 1 Left ventricular (LV) diastolic volume adjusted to body surface area as measured by (A) two-dimensional (2D) echocardiography and (B) three-dimensional (3D) echocardiography at baseline, 1 day, and 6 months after patent ductus arteriosus (PDA) closure in the whole PDA group and in patients with normal-sized LV at baseline and in control group. _*p < 0.05; p < 0.01; p < 0.001 as compared with control group; p < 0.05, ¶p < 0.01 within PDA group as compared with baseline.