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Figure 1 Aortic valve area (AVA) (open circles) and body weight (closed circles) evolution during the study in wild-type mice fed with a normal diet (A) or a high-fat/high-carbohydrate (HF/HC) diet (B). (C) Maximal transvalvular velocities (cm/s) over time during the study. Results are presented as mean ± SEM. *p < 0.05; **p < 0.01 vs. baseline (month 0) by repeated measures analysis of variance with Tukey post-hoc test. ##p < 0.01 between indicated values by unpaired t test.