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Figure 4 Expression of markers of apoptosis after repeated I/R. (A) Representative Western blots of two samples from each group (except in sham) from myocardial samples obtained 12 h after the last episode of intermittent I/R. (B) Bcl-2 and Bcl-xl were highly induced in lacZ-treated animals, while phospho-bad was elevated in the HO-1–treated animals. There was no change in levels of bax and alpha-sacrcomeric actin levels. HO-1–injected animal without I/R injury was used as a negative control. Abbreviations as in Figure 1.