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Figure 2 Effect of heme-oxygenase (HO)-1 gene transfer and repeated I/R on ventricular function. (A) Echocardiographic analyses of rat myocardium 12 days after the last ischemic episode demonstrates significant improvement in ejection fraction in HO-1-treated animals as compared to lacZ-treated controls. (* vs. sham; ** vs. lac Z. p < 0.05, n = 5 to 6/group). (B) Representative picture of M-Mode echocardiogram showing significant increase in left ventricle cavity and decrease in wall thickness in lacZ-treated animals when compared to HO-1-treated group. Other abbreviations as in Figure 1.