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Figure 7 Midostaurin enhances vasodilator response of SHR aorta. SHR were treated orally with vehicle (Co) or midostaurin (Mido, 75 mg/kg/day) for five days and aortic rings were prepared. Vasodilator response to acetylcholine was assayed in organ chambers after precontraction with 100 nmol/l norepinephrine in the absence or presence of the NOS inhibitor L-NAME (1 mmol/l). Symbols represent mean ± SEM of experiments performed with nine different aortas each (**p < 0.01, compared with Co, tested by ANOVA for repeated measures). Abbreviations as in Figure 1.