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Figure 2 The whole cohort was divided into tertiles of homeostasis model assessment of insulin resistance (HOMA-IR), such that the lowest tertile is most insulin sensitive and the highest tertile most resistant. The same levels of HOMA-IR were then applied to define the subgroups within positive family history (FH+) and negative family history (FH–) groups. There was reduced endothelium-dependent vasodilation (EDV) in the most resistant persons of the whole cohort, and in the most insulin-resistant FH– group as compared to with either of the two more sensitive subgroups; however, there was no relationship between HOMA-IR and EDV in FH+, such that even the most insulin-sensitive offspring had attenuated EDV. *p < 0.05.