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Figure 3 Pre-debulking gray scale intravascular ultrasound images, color-coded maps of pre- and post-debulking target lesions reconstructed by Virtual Histology intravascular ultrasound, and histology sections. (Case 1) Acute coronary syndrome. (1a) Gray scale intravascular ultrasound image at the target lesion. Note the heterogeneity of the plaque beside the plate of calcium with acoustic shadow. (1b) Pre-debulking color-coded map of 1a reconstructed by virtual histology intravascular ultrasound. Note the superficial necrotic core (red) beside the plate of the dense calcium (white). (1c) Post-debulking color-coded map. Predicted debulking area within the blue circle in 1b. (1d) Histologic finding with fibrous tissue, fibro-fatty plaque, and necrotic core. (Case 2) Stable angina pectoris. (2a) Gray scale intravascular ultrasound image of target lesion. Note the heterogeneity of the plaque. (2b) Pre-debulking color-coded map of 2a reconstructed by virtual histology intravascular ultrasound. Note the necrotic core (red) with thick fibrous cap consisting of fibrous tissue (green) and fibro-fatty plaque (yellow). (2c) Post-debulking color-coded map. Predicted debulking area within the blue circle in 2b. (2d) Histologic finding with fibrous tissue and fibro-fatty plaque. Bars = 500 µm.