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Figure 5 Polar map showing a perfusion defect before (Caffeine –) and after caffeine (Caffeine +). A 53-year-old white woman with diabetes mellitus, hypertension, dyslipidemia, and a history of moderate coronary artery disease underwent adenosine single-photon emission computed tomography for evaluation of chest pain. The baseline and caffeine study showed two-vessel ischemia with no significant difference in extent and severity of the defect between the two studies (caffeine blood level 2 mg/l). LAD = left anterior descending coronary artery; LCX = left circumflex coronary artery; RCA = right coronary artery; TOT = total.