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Figure 3 (A) Scatter plot of percent total defect size with (Caffeine +) and without (Caffeine –) caffeine. (B) Bland-Altman plot of the difference of the percent total defect sizes between the study with caffeine (Caffeine +) and the study without caffeine (Caffeine –) versus average percent total defect size. The data are compatible with the hypothesis that the mean Caffeine (+) and Caffeine (–) percent defect size difference is 0 (t test p value = 0.61). For percent defect size, the empirical variance of within-patient differences is 2.46%, which for n = 30 yields a 95% confidence interval for the mean difference with half-width <1% (0.92%).