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Figure 2 Patterns of vascular changes at proximal (top panels) and distal edges (bottom panels). In the bare-metal stent group (left), negative remodeling (reduction in external elastic membrane [EEM] volume), led to a reduction in luminal volume despite small reductions in plaque volume. In the sirolimus-eluting stent group (right), vessel enlargement (increase in EEM volume) encompassed an increase in plaque volume, resulting in a net gain in lumen volume. *p = 0.09; p = 0.04; p = 0.05; p = 0.001; ¶p = 0.03 (post-procedure versus 9-month follow-up p values).