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Figure 5 Incremental and early mortality risks. *Total HR = 1.20 (1.11, 1.30) when Smith et al. (5) (2005) removed (disproportionately large sample size of hospitalized elderly) with heterogeneity X2, p = 0.84. Results not significantly different when using Smilde et al. (24) for PRIME-II results instead of Hillege et al. (2) or when Akhter et al. (22) removed (New York Heart Association functional class IV only). CI = confidence interval; HR = hazard ratio.