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Figure 2 Flow chart of the study protocol. *At three months, the patients underwent a trial procedure of QoL testing and CPET, which were not used for further data analysis. AVDO = optimization of the programmed atrioventricular delay; BV = biventricular; CPET = cardiopulmonary exercise testing; Echo = echocardiography; NT-proBNP = N-terminal pro-B-type natriuretic peptide; NYHA = New York Heart Association; PM-FU = pacemaker follow-up; QoL = quality of life as assessed by the Minnesota Living with Heart Failure questionnaire; RV = right ventricular.