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Figure 3 Receiver-operating characteristic curves comparing the performance of amino-terminal pro-brain natriuretic peptide for the diagnosis of acute congestive heart failure in breathless subjects with normal-to-mild renal insufficiency (glomerular filtration rate [GFR] 60 ml/min/1.73 m², n = 393) versus moderate-to-severely impaired renal function (GFR <60 ml/min/1.73 m², n = 206). The difference between the two curves was not statistically significant (p = 0.34). AUC = area under the curve.