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Figure 2 Molecular pathway. Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibits cholesterol synthesis and isoprenoid production (geranyl-geranyl pyrophosphate and farnesyl pyrophosphate). This in turn reduces prenylation of G proteins such as Rho, and hence membrane binding. Illustration by Rob Flewell.