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Figure 2 (A) QT-RR (open circles) intervals of patients under sotalol (1 to 9.9 mg/kg/day) therapy. Filled circles = a 50-day-old infant (4.1 mg/kg/day); large filled circles = 8-year-old child (2.9 mg/kg/day). Solid line = fit of baseline neonate/infant QT-RR data dotted line: a fit of baseline children/adolescent data. (B) Differences of QTc_POP intervals from baseline in neonates (filled circles) and all other pediatric patients (open circles) versus sotalol concentration. (C) Sensitivity of the QTc interval prolongation towards sotalol (dQTc_POP).