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Figure 3 Effects of L-NMMA and vitamin C on cocoa effects. Both flow-mediated dilation (FMD) (A and C) and the circulating NO pool in plasma (RXNO) (B and D) increased 2 h after ingestion of cocoa containing 176 to 185 mg of flavanols. Whereas L-NMMA (A and B) reversed both parameters below baseline values, ascorbic acid (2 g, C and D) did not cause a further increase when given after measurements at the 2-h time point. Significance levels corrected for 8 pairwise comparisons in RXNO and FMD. Columns represent means ± SE (n = 4 smokers).