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Figure 2 Histologic example of a high-risk, vulnerable plaque. (a) Large lipid-rich core with a thin fibrous cap. The lumen contains contrast medium injected postmortem. (b) Higher magnification showing macrophages (>25 per high-power field) beneath a very thin cap (<65 µm in thickness). Extravasated erythrocytes with plaque hemorrhage within the core indicate plaque rupture nearby. Trichrome stain, rendering lipid colorless, collagen blue, and erythrocytes red. Adapted with permission from Schaar JA, et al. Eur Heart J 2004;25:1077–82.