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Figure 1 Representative examples illustrating the spectrum of ^99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (^99mTc-DPD) uptake among patients with transthyretin (TTR)-related or monoclonal immunoglobulin light-chain (AL) cardiac amyloidosis and unaffected controls (top row = whole-body scans, anterior view; bottom row = cross sectional views of cardiac single-photon emission computed tomography in the same patients). (A) Unaffected control subject without visually detectable uptake. (B) Patient with AL amyloidosis and echocardiographic documentation of cardiac involvement without any visually detectable sign of myocardial ^99mTc-DPD uptake; mild uptake of the tracer is visible only at the soft tissue level. (C and D) Two patients with TTR-related amyloidosis and echocardiographic documentation of cardiac involvement, both showing strong myocardial ^99mTc-DPD uptake (with absent bone uptake); in one of the patients (D), splanchnic uptake is also visible.