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Figure 2 Forearm blood flow (FBF) increase during infusion of acetylcholine (ACh). As shown, ACh-stimulated FBF was significantly reduced in hypertensive subjects (HTs) in comparison to normotensive control (NTs) subjects. Intra-arterial coinfusion of L-arginine (L-Arg) induced a further significant enhancement in ACh-stimulated vasodilation in HT patients.