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Figure 3 Cumulative risk of progression to New York Heart Association (NYHA) functional classes III and IV, or heart failure (HF) or stroke death related to age at initial evaluation and gender. Patients who were already in NYHA functional classes III to IV at initial evaluation were excluded from this analysis. Female patients >50 years versus female patients 50 years of age (p < 0.005); male patients >50 years versus male patients 50 years of age (p = 0.02).