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Figure 3 Effect of reversal of transmural sequence of activation in canine LV wedge preparation. Epicardial (Epi), endocardial (Endo), and M-cell action potentials and a transmural electrocardiogram were simultaneously recorded during endocardial (A) and epicardial (B) pacing at a basic cycle length of 2,000 ms. All numbers are in milliseconds. ECG = electrocardiogram; other abbreviations as in Figure 2. Modified and reprinted, with permission, from Fish et al. (5).