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Figure 4 Right anterior oblique (RAO) and left lateral oblique (LAO) fluoroscopic images of electrode placement during OPTIMIZER System implant. One lead is placed in the right atrium (RA), and two leads are placed on the right ventricular septum (RV1, RV2) approximately mid-way between the base and apex, one near the anterior and one near the posterior interventricular groove. The LAO caudal view shows the electrode tips point toward the left side of the patient’s body, into the septum. A micromanometer (Millar) is placed temporarily to measure physiologic response to acute cardiac contractility modulating signal application.