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Figure 5 Histology of infarcted hearts. Four weeks after infarction, hearts were excised, sectioned at the level of the papillary muscles, and stained with Masson’s trichrome (A, scale bar = 1 mm, B, scale bar = 200 µm). More preservation of muscular architecture and greater number of peri-infarct vessels seen in HIF-1(+) hearts compared to HIF-1(–) controls. Immunohistochemical staining with anti-CD31 monoclonal antibody in HIF-1(+) and HIF-1(–) hearts (n = 10 for each group) 4 weeks after coronary ligation in the peri-infarct region (C, scale bar = 45 µm).