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Figure 2 Many stimuli initiate transcription of genes in endothelium that encode protein mediators of inflammation and hemostasis. Statins and fibrates might modulate this process by inhibiting activation of nuclear transcription factor, NF-kappaB. Angiotensin-converting enzyme (ACE) inhibitors or angiotensin II type I receptor blockers (ARBs) modulate this process by inhibiting binding of angiotensin II to type I receptor, which decreases activation of NF-kappaB by oxygen free radicals. Modified from Koh KK (2).