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Figure 3 Estimated change in the five-year relative risk of stroke associated with mean LDL-C reduction for the statin trials* (dashed line) along with the 95% probability interval (dotted line). The solid line has a slope = 1. The crude risk estimates from the individual studies are plotted along with their associated 95% confidence intervals. LDL-C = low-density-lipoprotein cholesterol. Study acronyms: 4S = Scandinavian Simvastatin Survival Study; WOSCOPS = West of Scotland Coronary Prevention Study; CARE = Cholesterol And Recurrent Events study; LIPID = Long-Term Intervention with Pravastatin in Ischemic Disease; HPS = Heart Protection Study; PROSPER = PROspective Study of Pravastatin in the Elderly at Risk; ASCOT-LLA = Anglo-Scandinavian Cardiac Outcomes Trial–Lipid Lowering Arm; CARDS = Collaborative Atorvastatin Diabetes Study. *Only statin trials reported stroke incidence.