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Figure 1 Endothelial dysfunction in old subjects. Whereas (A) flow-mediated dilation (FMD) was significantly impaired in old subjects (n = 20, solid columns), (B) dilation after 400 µg of sublingual glycerol-trinitrate (GTN) was not (n = 20, open columns). (C) A decreased FMD/GTN ratio in the elder group implies specific endothelial dysfunction. Columns are mean ± SE.