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Figure 5 Mean inhibition of platelet cyclooxygenase-1 activity ex vivo (solid circles) (as assessed by measurement of serum TXB₂) and arachidonic acid-induced platelet aggregation ex vivo (open circles) in subjects taking a single dose of aspirin (100 mg) and naproxen (500 mg). Values are reported as mean ± SEM, n = 5. Serum TXB₂ and platelet aggregation were significantly inhibited versus pre-drug values at 3 h (p < 0.01 and 0.05, respectively), 12 h (p < 0.01), 24 h (p < 0.01), and 48 h (p < 0.01 and 0.05, respectively) after dosing. No significant differences were found at 1, 72, 144, 192, and 336 h after dosing versus pre-drug values. Open circles = platelet aggregation; solid circles = serum TXB₂.