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Figure 4 Mean inhibition of monocyte cyclooxygenase-2 activity ex vivo, as assessed by measurement of whole-blood lipopolysaccharide (LPS)-induced prostaglandin (PG)E₂ levels in subjects taking low-dose aspirin alone (100 mg daily) for 6 days (hatched bars) and then readministered with naproxen (500 mg twice daily, with the first dose administered 2 h after aspirin) for a further 6 days (open bars). The solid bars show the effect of the same medications, administered in reversed order for further six days after a washout period of 14 days, on monocyte cyclooxygenase-2 activity. The values are reported as mean ± SEM of inhibition (%) of LPS-induced PGE₂ levels caused by the different treatments, n = 4. *p < 0.05, **p < 0.01 versus pre-drug values. All times are hours after the administration of the first study drug. Open bars = aspirin before naproxen (twice daily); solid bars = naproxen (twice daily) before aspirin; hatched bars = aspirin.