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Figure 5 The effect of C-type natriuretic peptide (CNP) on collagen synthesis via the cyclic guanosine monophosphate (cGMP)/cyclic guanosine monophosphate-dependent protein kinase (PKG) pathway in cultured neonatal rat cardiac fibroblasts. (A and B) The effect of CNP and 8-Bromo cGMP on [³H]proline incorporation in cardiac fibroblasts. (C) [³H]proline incorporation in the presence or absence of 10^–8 mol/l CNP with or without Rp-8-pCPT-cGMP, PKG inhibitor. Values are mean ± SEM. **p < 0.01, *p < 0.05 compared with control by analysis of variance and Bonferroni multiple-comparison t test.