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Figure 3 Effects of hydroxyfasudil on serotonin-induced coronary vascular responses in dogs in vivo. Hydroxyfasudil converted the serotonin-induced vasoconstriction of small arteries to vasodilation (a) and significantly enhanced the serotonin-induced vasodilation of arterioles (b). L-NMMA significantly attenuated the serotonin-induced vasodilation, which was counteracted by hydroxyfasudil. Number of vessels per animal used was 18/6 for S, L + S and HF + S, 13/4 for L + HF + S. *p < 0.05, **p < 0.01. S = serotonin; L = L-NMMA; HF = hydroxyfasudil; B = before drug; A = after drug.