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Figure 7 Predictive value of pregnancy-associated plasma protein A (PAPP-A) in patients with acute chest pain for the incidence of death and nonfatal myocardial infarction (MI) during 30 days of follow-up (a). In patients that were negative both for troponin T (TnT) and soluble CD40 ligand (sCD40L), PAPP identified a subgroup suffering from increased cardiovascular risk during 30 days of follow-up (b). Diagnostic thresholds were 12.6 mIU/l for PAPP-A, 0.1 µg/l for TnT, and 5.0 µg/l for sCD40L (n = 644). Solid lines = TnT high; dotted lines = TnT low; open bars = PAPP-A low; solid bars = PAPP-A high.