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Figure 2 Pharmacological inhibition of SH2-domain containing tyrosine phosphatase-1 by sodium stibogluconate (SS) increases basal endothelial superoxide (O2·–) production. Pretreatment with SS (10 µg/ml) significantly enhanced O2·– release from human umbilical vein endothelial cells monolayers. The effect of SS reached significant levels after 30 min of preincubation, indicating a nontranscriptional mechanism. **Significantly different vs. control at p < 0.01.