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Figure 1 SH2-domain containing tyrosine phosphatase-1 (SHP-1) is constitutively active in endothelial cells and degraded by antisense-magnetofection. Magnetofection of antisense oligodesoxynucleotide (AS-ODN) against SHP-1 into human umbilical vein endothelial cells (HUVEC) resulted in deprivation of its protein associated with a loss of SHP-1 activity. Note that there is remarkable activity of SHP-1 in HUVEC grown under control conditions (random ODN, similar activity observed in untransfected cells, see Fig. 4). **Significantly different vs. control at p < 0.01.