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Figure 4 (A to D) Linear regression analysis showing the relationship between plasma levels of CD144-EMP or soluble intercellular adhesion molecule-1 (sICAM-1) and percentage change in coronary artery luminal diameter at the proximal segment of LAD in response to intracoronary acetylcholine (10 µg/min, 50 µg/min at left main trunk coronary artery [LMT]) infusion. Open circles are nondiabetic control patients and filled circles are patients with DM. (E to F) Correlation between plasma levels of CD144-EMP or sICAM-1 and percent increase from baseline values of coronary blood flow in response to intracoronary infusion of acetylcholine (10 µg/min at LMT). Open circles are nondiabetic control patients and filled circles are patients with DM. Abbreviations as in Figures 1 to 3.