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Figure 1 Schematic diagram showing structure of PCSK9 and exons/introns, location of single nucleotide polymorphisms (SNPs), and polymorphisms. Segments of the gene corresponding to neural apoptosis-regulated convertase-1 domains are shown. The reference number (rs) and the frequency (f) of the less common allele for each SNP are also shown. Polymorphisms shown in boxes, representing the L_n short tandem repeat, nonsynonymous coding SNPs, and those located in intron-exon boundaries, were genotyped and analyzed for haplotype reconstruction and linkage disequilibrium studies.