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Figure 3 Effect of high-dose folate on coronary dilator reserve. Dilator reserve was measured in normal (WNL) and abnormal (ABNL) regions. Mean data and standard error bars are depicted. Folate increased dilator reserve by 83% in abnormal segments (0.72 ± 0.60 ml/min/g vs. 1.31 ± 1.08 ml/min/g, mean ± SD, placebo vs. folate, p < 0.05), whereas dilator reserve in normal segments remained unchanged (2.00 ± 0.61 ml/min/g vs. 2.12 ± 0.69 ml/min/g, placebo vs. folate, p = NS). Open bars = placebo; solid bars = folate.