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Figure 10 Generation of prothrombin fragment (F1+2) by monocytes stimulated with CD40 ligand (CD40L) (50 ng/ml) and CD40L-stimulated monocytes added with 50 or 100 µmol/l of vitamin C in healthy subjects (open bars; n = 4) (A) and patients with hypercholesterolemia (solid bars; n = 4) (B). *p < 0.003 for CD40L (50 ng/ml)-stimulated monocytes added with 50 µmol/l of vitamin C versus CD40L (50 ng/ml)-stimulated monocytes. **p < 0.002 for CD40L (50 ng/ml)-stimulated monocytes added with 100 µmol/l of vitamin C versus CD40L (50 ng/ml)-stimulated monocytes.