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Figure 1 Antithrombotic effect versus dose, for four different anticoagulant agents, in a rat model of arterial thrombosis. The direct thrombin inhibitors melagatran (triangles) and inogatran (squares) were administered by continuous infusion throughout the experiment; warfarin was administered once daily for four consecutive days (circles); and heparin was administered by infusion (broken line). Warfarin (µmol/kg per day); melagatran and inogatran (µmol/kg per h); heparin (kU/kg per h). The slope of the dose-response curve (the Hill coefficient) for each agent is given in parentheses.