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Figure 5 Immunostaining of mast cells (MC) in normal (A) and stenotic (B) aortic valves. (A) Section of a normal aortic valve showing a few MCs (arrows) in a subendothelial location. (B) Section of a stenotic aortic valve demonstrating MC distribution throughout the leaflet and association of MCs with the calcified lesions of the valves (one arrow).