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Figure 3 Impact of initiating carvedilol before perindopril therapy (beta-blocker [BB]-first group) compared with the effect of the commencement of perindopril first (angiotensin-converting enzyme inhibitor [ACEI]-first group) on plasma N-terminal-pro-brain natriuretic peptide (NT-pro-BNP) concentrations. *p < 0.0005 versus baseline data (0 months); p < 0.01 versus absolute values and change from baseline in the ACEI-first group.