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Figure 2 Immunolocalization of fibrillar collagen type I by a three-layer immunoperoxidase technique. Sham-operated animals demonstrated constitutive collagen type I expression throughout the myocardium (a). In contrast, myocardium from vehicle-treated myocardial infarction (MI) animals demonstrated increased deposition of collagen type I in both the non-infarct and peri-infarct zones (b,d) and in the infarct regions (f). The MI animals treated with RWJ-67657 demonstrated less collagen type I immunoreactivity in each region compared with vehicle-treated MI animals (c, e, g). (Magnification: x200.)