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Figure 3 Transcranial arterio-venous oxygen difference, near infrared spectroscopy (NIRS)-tissue oxygenation index, peak transcranial Doppler velocity, and mean transcranial Doppler velocity at CO₂ 35, 45, 55, and 40 mm Hg. The lines represent individual patient values, with the bold line indicating the mean value. Peak and mean transcranial Doppler measurements were not available at an arterial carbon dioxide tension (PaCO₂) of 40 mm Hg in four patients. *Adjusted p value for difference between PaCO₂ 35 and 45 mm Hg. Adjusted p value for difference between PaCO₂ 45 and 55 mm Hg. Adjusted p value for difference between PaCO₂ 55 and 40 mm Hg.