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Figure 2 Hemodynamic and oxygenation response to inhaled nitric oxide (NO), oral sildenafil, oral vardenafil, and oral tadalafil. Deviations from the pre-intervention baseline value are displayed (point estimates of median difference [percentage of baseline = symbols], with exact 95% confidence intervals [bars] for inhaled NO [NO 20 to 40 ppm = solid circles], oral sildenafil [Sil 50 mg = red squares], 10 and 20 mg oral vardenafil [Vard 10 mg and Vard 20 mg = blue diamonds], and 20, 40, and 60 mg oral tadalafil [Tada 20 mg, Tada 40 mg, Tada 60 mg = green inverted triangles]). mSAP = mean systemic arterial pressure; CI = cardiac index; pO₂ = partial pressure of arterial oxygen. The p values indicate significant differences of treatment effects, as determined by one-way analysis of variance. ¶Different from NO. ||Different from tadalafil 60 mg (p < 0.05, Scheffé post-test).