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Figure 2 Mean combined carotid intima media thickness (IMT) increase per year of age is significantly higher in heterozygotes compared with controls. The rate of progression of carotid wall thickening over time is similar in L178P heterozygotes and familial hypercholesterolemia (FH) patients. Solid circles = ApoA-I (L178P) carriers; open diamonds = patients with FH; + = family controls.